Role of Type I (Neuronal) Nitric Oxide Synthase in Pulmonary Vascular Tone in the Ovine Fetus ♦ 348
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چکیده
منابع مشابه
Role of inducible nitric oxide synthase in the pulmonary vascular response to birth-related stimuli in the ovine fetus.
To determine whether type II nitric oxide synthase (NOS II) contributes to the NO-mediated fall in pulmonary vascular resistance (PVR) at birth, we studied the effects of selective NOS II antagonists N-(3-aminomethyl) benzylacetamidine dihydrochloride (1400W) and aminoguanidine (AG) and a nonselective NOS antagonist, nitro-L-arginine (L-NA), during mechanical ventilation with low FIO(2) (<10%),...
متن کاملModulation of Renal Blood Flow and Vascular Tone by Neuronal Nitric Oxide Synthase-Derived Nitric Oxide
Nitric oxide (NO) formed via neuronal nitric oxide synthase (nNOS) in renal vasculature and tissues and in the brain plays an important role in controlling renal hemodynamics, renal function, and systemic blood pressure. Activation of parasympathetic nitrergic nerves innervating renal vasculature contributes to vasodilatation in renal arteries and preand postglomerular arterioles, an increase i...
متن کاملModulation of renal blood flow and vascular tone by neuronal nitric oxide synthase-derived nitric oxide.
Nitric oxide (NO) formed via neuronal nitric oxide synthase (nNOS) in renal vasculature and tissues and in the brain plays an important role in controlling renal hemodynamics, renal function, and systemic blood pressure. Activation of parasympathetic nitrergic nerves innervating renal vasculature contributes to vasodilatation in renal arteries and pre- and postglomerular arterioles, an increase...
متن کاملFeedback control of glomerular vascular tone in neuronal nitric oxide synthase knockout mice.
For further elucidation of the role of neuronal nitric oxide synthase (nNOS) in macula densa (MD) cells, experiments were performed in anesthetized nNOS knockout mice (nNOS -/-). At comparable levels of arterial BP, renal blood flow was not significantly different between nNOS +/+ and nNOS -/- (1.7 +/- 0.2 versus 1.4 +/- 0.1 ml/min), and autoregulation of renal blood flow was maintained to a pr...
متن کاملNeuronal Nitric Oxide Synthase in Vascular Physiology and Diseases
The family of nitric oxide synthases (NOS) has significant importance in various physiological mechanisms and is also involved in many pathological processes. Three NOS isoforms have been identified: neuronal NOS (nNOS or NOS 1), endothelial NOS (eNOS or NOS 3), and an inducible NOS (iNOS or NOS 2). Both nNOS and eNOS are constitutively expressed. Classically, eNOS is considered the main isofor...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1998
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199804001-00369